{
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  "Package": "locusviz",
  "Type": "Package",
  "Title": "Yet Another Locus Visualization Package in R",
  "Version": "0.3.0",
  "Author": "Masahiro Kanai",
  "Maintainer": "Masahiro Kanai <mkanai@broadinstitute.org>",
  "Description": "This package provides various functions to visualize GWAS\ndata for a locus of interest using ggplot2.",
  "License": "MIT + file LICENSE",
  "Encoding": "UTF-8",
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  "Repository": "https://mkanai.r-universe.dev",
  "Date/Publication": "2026-05-31 00:49:19 UTC",
  "RemoteUrl": "https://github.com/mkanai/locusviz",
  "RemoteRef": "HEAD",
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  "Packaged": {
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    "author": "Masahiro Kanai <mkanai@broadinstitute.org>",
    "committer": "Masahiro Kanai <mkanai@broadinstitute.org>",
    "message": "Add GENCODE v39 hg38 gene models from gnomAD v4.1.1\n\nUpdate the hg38 gene annotation resources to GENCODE v39, matching the\ngene models used by gnomAD v4.1.1 (VEP v105). Canonical transcripts are\nderived from the gnomAD v4.1.1 genomes sites HT.\n\n- canonical_transcripts.py: read v4.1.1 genomes sites HT, export v39 tsv\n- gencode_txdb(): hg38 now uses GENCODE release_39 GTF + v39 canonical tsv;\n  switch GTF URLs to https and raise download.file timeout (ftp host was\n  timing out on the ~55 MB transfer)\n- write_txdb_files(): build txdb_v39_hg38.sqlite + tss_v39_hg38 (also fixes\n  a stale reference to an undefined txdb_v34_hg38)\n- load_txdb(\"hg38\") now defaults to txdb_v39_hg38.sqlite\n- Add inst/extdata/{canonical_transcripts_grch38_v39.tsv.gz,\n  txdb_v39_hg38.sqlite} and data/tss_v39_hg38.RData with docs\n\nPrevious v19/v34/v35 resources are retained for consistency.\n\nCo-Authored-By: Claude Opus 4.8 (1M context) <noreply@anthropic.com>\n",
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    "compute_functional_enrichment",
    "distinct_shades",
    "gencode_txdb",
    "get_chromosome_sizes",
    "get_cs_color_mapping",
    "get_default_theme",
    "get_global_position",
    "get_gnomad_colors",
    "get_pfam_domains",
    "get_tss_gene_body",
    "highlight_vline",
    "jitter_labels",
    "liftover_variant",
    "load_txdb",
    "mean_ci",
    "median_ci",
    "na_and",
    "na_or",
    "normalize_rank",
    "or_else",
    "or_missing",
    "parse_variant",
    "plot_fm_panel",
    "plot_gene_panel",
    "plot_gene_score_panel",
    "plot_locuszoom",
    "plot_lollipop",
    "plot_manhattan_panel",
    "plot_r2_panel",
    "plot_upset",
    "plot_upset_bar",
    "plot_upset_matrix",
    "preprocess",
    "scale_color_chromosome",
    "scale_x_chromosome",
    "spearman_ci",
    "stat_summary_irq",
    "trans_loglog_p",
    "UpSet2",
    "variant_str",
    "variant_str2",
    "write_txdb_files"
  ],
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      "title": "TSS and gene body data for GENCODE v19 (hg19/GRCh37)",
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        "chromosome",
        "strand",
        "start",
        "end",
        "tss"
      ],
      "rows": 18824,
      "table": true,
      "tojson": true
    },
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      "object": "tss_v34_hg38",
      "class": [
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        "tbl",
        "data.frame"
      ],
      "fields": [
        "tx_id",
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        "chromosome",
        "strand",
        "start",
        "end",
        "tss"
      ],
      "rows": 19253,
      "table": true,
      "tojson": true
    },
    {
      "name": "tss_v39_hg38",
      "title": "TSS and gene body data for GENCODE v39 (hg38/GRCh38)",
      "object": "tss_v39_hg38",
      "class": [
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        "tbl",
        "data.frame"
      ],
      "fields": [
        "tx_id",
        "tx_name",
        "chromosome",
        "strand",
        "start",
        "end",
        "tss"
      ],
      "rows": 19310,
      "table": true,
      "tojson": true
    }
  ],
  "_help": [
    {
      "page": "annotate_hrange",
      "title": "Annotate horizontal range on a plot",
      "topics": [
        "annotate_hrange"
      ]
    },
    {
      "page": "annotate_r2",
      "title": "Annotate variants with linkage disequilibrium (r2) values",
      "topics": [
        "annotate_r2"
      ]
    },
    {
      "page": "binom_ci",
      "title": "Binomial confidence interval",
      "topics": [
        "binom_ci"
      ]
    },
    {
      "page": "boot_ci",
      "title": "Bootstrap confidence interval",
      "topics": [
        "boot_ci"
      ]
    },
    {
      "page": "compute_distance_to_gene",
      "title": "Compute distance from reference position to genes",
      "topics": [
        "compute_distance_to_gene"
      ]
    },
    {
      "page": "compute_functional_enrichment",
      "title": "Compute functional enrichment of variants by PIP bins",
      "topics": [
        "compute_functional_enrichment"
      ]
    },
    {
      "page": "distinct_shades",
      "title": "Generate distinct shades of a base color",
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      ]
    },
    {
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      "title": "Create a TxDb object from GENCODE annotations",
      "topics": [
        "gencode_txdb"
      ]
    },
    {
      "page": "get_chromosome_sizes",
      "title": "Get chromosome sizes and cumulative positions",
      "topics": [
        "get_chromosome_sizes"
      ]
    },
    {
      "page": "get_cs_color_mapping",
      "title": "Get color mapping for credible sets",
      "topics": [
        "get_cs_color_mapping"
      ]
    },
    {
      "page": "get_default_theme",
      "title": "Get default ggplot2 theme for locusviz plots",
      "topics": [
        "get_default_theme"
      ]
    },
    {
      "page": "get_global_position",
      "title": "Convert chromosomal position to global genomic position",
      "topics": [
        "get_global_position"
      ]
    },
    {
      "page": "get_gnomad_colors",
      "title": "Get gnomAD population colors",
      "topics": [
        "get_gnomad_colors"
      ]
    },
    {
      "page": "get_pfam_domains",
      "title": "Get Pfam domain annotations for a gene",
      "topics": [
        "get_pfam_domains"
      ]
    },
    {
      "page": "get_tss_gene_body",
      "title": "Extract TSS and gene body information from TxDb",
      "topics": [
        "get_tss_gene_body"
      ]
    },
    {
      "page": "highlight_vline",
      "title": "Add vertical highlight lines to a plot",
      "topics": [
        "highlight_vline"
      ]
    },
    {
      "page": "jitter_labels",
      "title": "Jitter labels to avoid overlapping",
      "topics": [
        "jitter_labels"
      ]
    },
    {
      "page": "liftover_variant",
      "title": "Liftover variant positions between genome builds",
      "topics": [
        "liftover_variant"
      ]
    },
    {
      "page": "load_txdb",
      "title": "Load transcript database for gene annotations",
      "topics": [
        "load_txdb"
      ]
    },
    {
      "page": "mean_ci",
      "title": "Mean confidence interval via bootstrap",
      "topics": [
        "mean_ci"
      ]
    },
    {
      "page": "median_ci",
      "title": "Median confidence interval via bootstrap",
      "topics": [
        "median_ci"
      ]
    },
    {
      "page": "na_and",
      "title": "NA-safe AND operation",
      "topics": [
        "na_and"
      ]
    },
    {
      "page": "na_or",
      "title": "NA-safe OR operation",
      "topics": [
        "na_or"
      ]
    },
    {
      "page": "normalize_rank",
      "title": "Normalize scores by rank with exponential decay",
      "topics": [
        "normalize_rank"
      ]
    },
    {
      "page": "or_else",
      "title": "Return first non-NA value",
      "topics": [
        "or_else"
      ]
    },
    {
      "page": "or_missing",
      "title": "Conditionally return value or NULL",
      "topics": [
        "or_missing"
      ]
    },
    {
      "page": "parse_variant",
      "title": "Parse variant string into components",
      "topics": [
        "parse_variant"
      ]
    },
    {
      "page": "plot_fm_panel",
      "title": "Create fine-mapping panel",
      "topics": [
        "plot_fm_panel"
      ]
    },
    {
      "page": "plot_gene_panel",
      "title": "Create gene track panel",
      "topics": [
        "plot_gene_panel"
      ]
    },
    {
      "page": "plot_gene_score_panel",
      "title": "Create gene score visualization panel",
      "topics": [
        "plot_gene_score_panel"
      ]
    },
    {
      "page": "plot_locuszoom",
      "title": "Create LocusZoom-style visualization",
      "topics": [
        "plot_locuszoom"
      ]
    },
    {
      "page": "plot_lollipop",
      "title": "Create lollipop plot for variant effects",
      "topics": [
        "plot_lollipop"
      ]
    },
    {
      "page": "plot_manhattan_panel",
      "title": "Create Manhattan plot panel",
      "topics": [
        "plot_manhattan_panel"
      ]
    },
    {
      "page": "plot_r2_panel",
      "title": "Create r² (linkage disequilibrium) panel",
      "topics": [
        "plot_r2_panel"
      ]
    },
    {
      "page": "plot_upset",
      "title": "Create UpSet plot for set intersections",
      "topics": [
        "plot_upset"
      ]
    },
    {
      "page": "plot_upset_bar",
      "title": "Plot UpSet bar panel",
      "topics": [
        "plot_upset_bar"
      ]
    },
    {
      "page": "plot_upset_matrix",
      "title": "Plot UpSet matrix panel",
      "topics": [
        "plot_upset_matrix"
      ]
    },
    {
      "page": "preprocess",
      "title": "Preprocess GWAS data for visualization",
      "topics": [
        "preprocess"
      ]
    },
    {
      "page": "scale_color_chromosome",
      "title": "Create chromosome color scale for Manhattan plots",
      "topics": [
        "scale_color_chromosome"
      ]
    },
    {
      "page": "scale_x_chromosome",
      "title": "Create chromosome x-axis scale for genome-wide plots",
      "topics": [
        "scale_x_chromosome"
      ]
    },
    {
      "page": "spearman_ci",
      "title": "Spearman correlation confidence interval",
      "topics": [
        "spearman_ci"
      ]
    },
    {
      "page": "stat_summary_irq",
      "title": "Summary statistic with interquartile range",
      "topics": [
        "stat_summary_irq"
      ]
    },
    {
      "page": "trans_loglog_p",
      "title": "Create log-log transformation for p-values",
      "topics": [
        "trans_loglog_p"
      ]
    },
    {
      "page": "tss_v19_hg19",
      "title": "TSS and gene body data for GENCODE v19 (hg19/GRCh37)",
      "topics": [
        "tss_v19_hg19"
      ]
    },
    {
      "page": "tss_v34_hg38",
      "title": "TSS and gene body data for GENCODE v34 (hg38/GRCh38)",
      "topics": [
        "tss_v34_hg38"
      ]
    },
    {
      "page": "tss_v39_hg38",
      "title": "TSS and gene body data for GENCODE v39 (hg38/GRCh38)",
      "topics": [
        "tss_v39_hg38"
      ]
    },
    {
      "page": "UpSet2",
      "title": "Modified UpSet plot",
      "topics": [
        "UpSet2"
      ]
    },
    {
      "page": "variant_str",
      "title": "Create variant string from components",
      "topics": [
        "variant_str"
      ]
    },
    {
      "page": "variant_str2",
      "title": "Create variant string from locus and alleles",
      "topics": [
        "variant_str2"
      ]
    },
    {
      "page": "write_txdb_files",
      "title": "Write TxDb and TSS data files",
      "topics": [
        "write_txdb_files"
      ]
    }
  ],
  "_readme": "https://github.com/mkanai/locusviz/raw/HEAD/README.md",
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