https://mkanai.r-universe.devRecent package updates in mkanaiR-universehttps://github.com/mkanai.pnghttps://mkanai.r-universe.devSun, 31 May 2026 18:27:49 GMTmkanai@broadinstitute.org (Masahiro Kanai)Provides a hierarchical framework for systematically characterizing cell type specificity and regulatory mechanisms of molecular QTLs (molQTLs) from multiome analyses. Gene- and peak-level analyses classify eGenes and caPeaks by their cell type specificity patterns, with power-aware assessment using local false sign rates (LFSR) from multivariate adaptive shrinkage (mash) to identify likely shared but underpowered features. Variant-level analysis classifies fine-mapped variants by regulatory mechanism, with 25 mutually exclusive QTL patterns collapsing into eight mechanism categories that include three chromatin-to-expression cascade tiers.https://github.com/r-universe/mkanai/actions/runs/26723144328Sun, 31 May 2026 18:27:49 GMTcascade1.0.0successhttps://mkanai.r-universe.devhttps://github.com/mkanai/cascadecascade-quickstart.Rmdcascade-quickstart.htmlGetting Started with CASCADE2026-05-15 04:30:342026-05-15 04:30:34mkanai@broadinstitute.org (Masahiro Kanai)This package provides various functions to visualize GWAS data for a locus of interest using ggplot2.https://github.com/r-universe/mkanai/actions/runs/26701587030Sun, 31 May 2026 00:49:19 GMTlocusviz0.3.0successhttps://mkanai.r-universe.devhttps://github.com/mkanai/locusvizmkanai@broadinstitute.org (Masahiro Kanai)Provides fast hurdle regression models for count data using C++ implementations via 'Rcpp'. Supports the same functionality as the hurdle function in the 'pscl' package, with improved performance for large datasets.https://github.com/r-universe/mkanai/actions/runs/25927955261Fri, 15 May 2026 15:51:13 GMTfasthurdle1.2.0successhttps://mkanai.r-universe.devhttps://github.com/mkanai/fasthurdlemkanai@broadinstitute.org (Masahiro Kanai)Extends the 'anndataR' package to provide Google Cloud Storage-backed AnnData functionality for R. This package allows users to work with AnnData objects stored in Google Cloud Storage without downloading the entire file, enabling efficient access to large single-cell datasets directly from the cloud.https://github.com/r-universe/mkanai/actions/runs/26936185563Thu, 02 Apr 2026 17:26:30 GMTGCSanndataR0.1.1successhttps://mkanai.r-universe.devhttps://github.com/mkanai/GCSanndataRmkanai@broadinstitute.org (Masahiro Kanai)Reads binary correlation (BCOR) files generated by LDStore into R's sparse matrix format. BCOR files store linkage disequilibrium correlation matrices in a compressed binary format.https://github.com/r-universe/mkanai/actions/runs/26937364421Fri, 06 Mar 2026 20:58:59 GMTrbcor1.0.0successhttps://mkanai.r-universe.devhttps://github.com/mkanai/rbcormkanai@g.harvard.edu (Masahiro Kanai)Grimon (Graphical interface to visualize multi-omics networks) visualizes high-dimensional multi-layered data sets in three-dimensional parallel coordinates. It enables users to intuitively and interactively explore their data, helping their understanding of multiple inter-layer connections embedded in high-dimensional complex data.https://github.com/r-universe/mkanai/actions/runs/26945558162Wed, 16 Mar 2022 10:31:35 GMTgrimon1.0.0successhttps://mkanai.r-universe.devhttps://github.com/mkanai/grimonmkanai@broadinstitute.org (Masahiro Kanai)This package is an experimental refactored version of the "WRS" package, which implements R. R. Wilcox' the robust statistics functions. The package currently focuses on implementing functions related to the Harrell-Davis estimator.https://github.com/r-universe/mkanai/actions/runs/26946691649Tue, 14 Jul 2020 16:50:55 GMTWRShd0.1successhttps://mkanai.r-universe.devhttps://github.com/mkanai/WRShdmasahiro.kanai@riken.jp (Masahiro Kanai)This package implements optimal matching of cases to controls at a given ratio by solving a minimum cost flow problem.https://github.com/r-universe/mkanai/actions/runs/26155445016Tue, 14 Jul 2015 14:28:53 GMTccmatch1.0successhttps://mkanai.r-universe.devhttps://github.com/mkanai/ccmatch